[Hereditary dysprothrombinemia with a mild bleeding tendency (prothrombin Magdeburg)].

Abstract

Seven members of one family over three generations were found to have a characteristic reduction to about 0.5 of the ratio between factor II clotting activity and factor II concentration, which was not seen when measuring prothrombin after activation with staphylocoagulase. In addition to the "normal" prothrombin, two abnormal prothrombins, with higher molecular weights and lower isoelectric points, were found by SDS-polyacrylamide gel electrophoresis. This is an autosomal hereditary dysprothrombinemia, the affected persons being heterozygotes. Five of the seven persons had a slightly increased bleeding tendency which manifested itself especially in more marked or prolonged posttraumatic and postoperative bleedings.

• Authors: G Lutze, U Frick, G Töpfer, H Urbahn
• Journal: Deutsche medizinische Wochenschrift (1946) (Dtsch Med Wochenschr) Vol. 114 Issue 8 Pg. 288-92 (Feb 24 1989) ISSN: 0012-0472 [Print] Germany
• Vernacular Title: Hereditäre Dysprothrombinämie mit geringer Blutungsneigung (Prothrombin Magdeburg).
• PMID: 2920673 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• prothrombin Magdeburg
• Prothrombin

Topics

• Blood Coagulation Disorders (blood, genetics)
• Blood Coagulation Tests
• Blood Protein Electrophoresis
• Child, Preschool
• Electrophoresis, Polyacrylamide Gel
• Female
• Hemorrhagic Disorders (blood, genetics)
• Humans
• Immunoblotting
• Isoelectric Focusing
• Male
• Molecular Weight
• Pedigree
• Platelet Count
• Prothrombin (analysis, genetics)