Abstract | BACKGROUND: METHODS: A multicenter, parallel-group, double-blind, placebo-controlled study was conducted including patients 18 years of age and older with an American Society of Anesthesiologist class of I-III undergoing laparoscopic surgery for suspected appendicitis. The primary outcome was pain at rest measured on the 11-point numerical rating scale 5 times during the first 3 days after surgery. The effect of 125 mg of methylprednisolone on postoperative pain at rest during the first 3 days was assessed using a mixed-effects model with time and intervention as main effects. RESULTS: From April 2016 to August 2016, 78 patients were included, and all were eligible for analysis of the primary outcome. The estimated effect of 125 mg of methylprednisolone on pain at rest during the first 3 days after surgery was a nonsignificant increase of 0.2 (95% confidence interval, -0.5 to 0.9; P = .571) on the 11-point numerical rating scale. There was no difference between the 2 groups regarding the need for opioid agonists during hospital stay on the first postoperative day (P = .381). CONCLUSIONS:
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Authors | Jakob Kleif, Camilla I Hauge, Jesper Vilandt, Ismail Gögenur |
Journal | Anesthesia and analgesia
(Anesth Analg)
Vol. 126
Issue 5
Pg. 1712-1720
(05 2018)
ISSN: 1526-7598 [Electronic] United States |
PMID | 29200067
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents
- Methylprednisolone
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Topics |
- Administration, Intravenous
- Adult
- Anti-Inflammatory Agents
(administration & dosage)
- Appendectomy
(adverse effects)
- Appendicitis
(diagnosis, epidemiology, surgery)
- Dose-Response Relationship, Drug
- Double-Blind Method
- Female
- Humans
- Laparoscopy
(adverse effects)
- Male
- Methylprednisolone
(administration & dosage)
- Middle Aged
- Pain, Postoperative
(diagnosis, epidemiology, prevention & control)
- Preoperative Care
(methods)
- Rest
(physiology)
- Young Adult
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