Abstract | BACKGROUND/AIM: MATERIALS AND METHODS: In this case-control study, 266 patients with childhood ALL and 266 non- cancer controls were genotyped by polymerase chain reaction-restriction fragment length polymorphism methodology. RESULTS: The distribution of AA, AG and GG for MMP7 promoter A-181G genotype was 83.5, 12.0 and 4.5% in the childhood ALL group and 89.8%, 9.4 and 0.8% in the non- cancer control group, respectively (p for trend=0.0134), significantly differentially distributed between childhood ALL and control groups. The comparisons in allelic frequency distribution also support the findings that G appears to be the risky allele in childhood ALL. In genotype and gender interaction analysis, it was found that boys carrying the MMP7 A-181G GG and AG+GG genotypes had 9.05- and 2.45-fold odds ratios ( ORs) (p=0.0135 and 0.0142, respectively) for childhood ALL compared to those carrying wild-type AA genotype. But these differences were not found in girls. Analysis of genotype interaction with age of onset age showed those aged less than 3.5 years at onset carrying the GG or AG+GG genotypes also had elevated ORs of 8.79- and 2.04-fold (p=0.0150 and 0.0413, respectively) for childhood ALL, but there was no such difference for those having an age at onset of 3.5 years or more. CONCLUSION: Our results indicate that the MMP7 A-181G genotype interacts with age and gender and may serve as an early and predictive biomarker for childhood ALL.
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Authors | Jen-Sheng Pei, An-Kuo Chou, Pei-Chen Hsu, Chia-Wen Tsai, Wen-Shin Chang, Meng-Feng Wu, Ming-Hsien Wu, Te-Chun Hsia, Shun-Ping Cheng, DA-Tian Bau |
Journal | Anticancer research
(Anticancer Res)
Vol. 37
Issue 12
Pg. 6679-6684
(12 2017)
ISSN: 1791-7530 [Electronic] Greece |
PMID | 29187444
(Publication Type: Journal Article)
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Copyright | Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved. |
Chemical References |
- Matrix Metalloproteinase 7
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Topics |
- Asian People
(genetics)
- Case-Control Studies
- Child
- Female
- Gene Frequency
- Genetic Predisposition to Disease
(ethnology, genetics)
- Genotype
- Humans
- Male
- Matrix Metalloproteinase 7
(genetics)
- Odds Ratio
- Polymorphism, Single Nucleotide
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
(ethnology, genetics)
- Promoter Regions, Genetic
(genetics)
- Risk Factors
- Taiwan
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