Atypical, non-standard functions of the microtubule associated Tau protein.

Abstract

Since the discovery of the microtubule-associated protein Tau (MAPT) over 40 years ago, most studies have focused on Tau's role in microtubule stability and regulation, as well as on the neuropathological consequences of Tau hyperphosphorylation and aggregation in Alzheimer's disease (AD) brains. In recent years, however, research efforts identified new interaction partners and different sub-cellular localizations for Tau suggesting additional roles beyond its standard function as microtubule regulating protein. Moreover, despite the increasing research focus on AD over the last decades, Tau was only recently considered as a promising therapeutic target for the treatment and prevention of AD as well as for neurological pathologies beyond AD e.g. epilepsy, excitotoxicity, and environmental stress. This review will focus on atypical, non-standard roles of Tau on neuronal function and dysfunction in AD and other neurological pathologies providing novel insights about neuroplastic and neuropathological implications of Tau in both the central and the peripheral nervous system.

• Authors: Ioannis Sotiropoulos, Marie-Christine Galas, Joana M Silva, Efthimios Skoulakis, Susanne Wegmann, Mahmoud Bukar Maina, David Blum, Carmen Laura Sayas, Eva-Maria Mandelkow, Eckhard Mandelkow, Maria Grazia Spillantini, Nuno Sousa, Jesus Avila, Miguel Medina, Amrit Mudher, Luc Buee
• Journal: Acta neuropathologica communications (Acta Neuropathol Commun) Vol. 5 Issue 1 Pg. 91 (Nov 29 2017) ISSN: 2051-5960 [Electronic] England
• PMID: 29187252 (Publication Type: Journal Article, Review)

Chemical References

• tau Proteins

Topics

• Alzheimer Disease (metabolism)
• Animals
• Humans
• tau Proteins (metabolism)