A case of heavily pretreated metastatic cardiac angiosarcoma treated successfully using eribulin.

Abstract

Eribulin mesylate (eribulin) is a nontaxane microtubule inhibitor approved in Japan for treating soft tissue sarcoma irrespective of histological subtypes. Thus, our department routinely uses eribulin to treat any histological subtype of sarcoma for patients who have experienced disease progression during standard therapy. However, evidence on the efficacy of eribulin in treating sarcomas that are neither liposarcoma nor leiomyosarcoma is limited. Recently, we encountered a case of a heavily pretreated cardiac angiosarcoma that responded well to eribulin treatment. The patient was a 34-year-old Japanese woman with advanced angiosarcoma, who had been pretreated heavily using several lines of chemotherapy. Eribulin was administered as the eighth line of treatment and the dose was adjusted because of grade 4 neutropenia. After three cycles of treatment, contrast-enhanced computed tomography showed a partial tumor response, which was sustained for ~4 months. This case suggests that eribulin may be a potential therapeutic option for angiosarcoma. Further studies are needed to confirm the benefit of eribulin for patients with angiosarcoma and to establish predictive markers for eribulin sensitivity.

• Authors: Chiaki Inagaki, Tatsunori Shimoi, Hitomi Okuma, Akiko Kitano, Akihiko Shimomura, Emi Noguchi, Makoto Kodaira, Mayu Yunokawa, Kan Yonemori, Chikako Shimizu, Akihiko Yoshida, Yasuhiro Fujiwara, Kenji Tamura
• Journal: Anti-cancer drugs (Anticancer Drugs) Vol. 29 Issue 1 Pg. 97-101 (01 2018) ISSN: 1473-5741 [Electronic] England
• PMID: 29176397 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antineoplastic Agents
• Furans
• Ketones
• eribulin

Topics

• Adult
• Antineoplastic Agents (therapeutic use)
• Female
• Furans (therapeutic use)
• Heart Neoplasms (drug therapy, surgery)
• Hemangiosarcoma (drug therapy, surgery)
• Humans
• Ketones (therapeutic use)