Abstract | PURPOSE: MATERIALS AND METHODS: The localization of μ- opioid receptors and neuronal NO synthase (nNOS) in the rat retina was examined using immunohistochemistry. The retinal vascular responses were evaluated by measuring the diameter of retinal arterioles in in vivo fundus images. Both systemic blood pressure and heart rate were continuously recorded. RESULTS: CONCLUSION: These results suggest that retinal glial cells play an important role in the μ- opioid receptor-mediated retinal vasodilation in rats. Stimulation of μ- opioid receptors on retinal ganglion cells may affect the activity of glial cells, thereby changing retinal vascular tone.
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Authors | Eriko Someya, Asami Mori, Daiki Asano, Akane Morita, Kenji Sakamoto, Tsutomu Nakahara |
Journal | Current eye research
(Curr Eye Res)
Vol. 43
Issue 3
Pg. 350-356
(03 2018)
ISSN: 1460-2202 [Electronic] England |
PMID | 29172736
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- 9-(benzoyloxy)-2-(3-furanyl)dodecahydro-6a,10b-dimethyl-4,10-dioxo-2H-naphtho(2,1-c)pyran-7-carboxylic acid methyl ester
- Furans
- Pyrones
- Receptors, Opioid, mu
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Topics |
- Animals
- Arterioles
(drug effects, physiology)
- Furans
(pharmacology)
- Immunohistochemistry
- Male
- Models, Animal
- Neuroglia
- Pyrones
(pharmacology)
- Rats
- Rats, Wistar
- Receptors, Opioid, mu
(metabolism)
- Retinal Vessels
(drug effects, physiology)
- Vasodilation
(physiology)
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