Microcystic Stromal Tumor of Testicle: First Case Report and Literature Review.

Abstract

Microcystic stromal tumor (MCST) is a rare subtype of sex cord-stromal neoplasm. Tumors from all 31 previously reported cases were located in the ovary. Herein, we present a unique case of a right-side testicular tumor in a 33-year-old Chinese male. The tumor is composed of predominantly lobulated cellular nodules separated by hyalinized fibrous stroma and they expressed CD10, β-catenin (nuclear), and cyclin D1. Molecular analysis identified a point mutation (c.110C>G) in exon 3 of CTNNB1. The histopathological features, immunohistochemistry profiles, and molecular analysis of this tumor were consistent with MCST of the ovary. Therefore, a diagnosis of MCST of the right testicle was determined. To the best of our knowledge, this is the first case of MCST occurring in the testicles. The study may provide new insights to the tumor biology of MCST and a better understanding of this rare entity.

• Authors: Pengcheng Zhu, Yaqi Duan, Qilin Ao, Guoping Wang
• Journal: Cancer research and treatment (Cancer Res Treat) Vol. 50 Issue 4 Pg. 1452-1457 (Oct 2018) ISSN: 2005-9256 [Electronic] Korea (South)
• PMID: 29169232 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• CCND1 protein, human
• CTNNB1 protein, human
• beta Catenin
• Cyclin D1
• Neprilysin

Topics

• Adult
• Cyclin D1 (metabolism)
• Humans
• Male
• Neprilysin (metabolism)
• Point Mutation
• Sex Cord-Gonadal Stromal Tumors (diagnostic imaging, genetics, metabolism)
• Testicular Neoplasms (diagnostic imaging, genetics, metabolism)
• beta Catenin (genetics, metabolism)