Abstract | INTRODUCTION: Oral verrucous carcinoma is a special form of well-differentiated squamous cell carcinoma which possesses specific clinical, morphologic and cytokinetic features that differ from other types of oral cancers and hence diagnosis requires immense experience in histopathology. Hence it is certainly important to distinguish such a lesion from other oral tumors as treatment strategies vary widely between them. OBJECTIVE: METHODS: Ten patients reported positive for oral cancer (5 patients with oral verrucous carcinoma and 5 patients with oral squamous cell carcinoma). Five normal tissue samples were also obtained and evaluated for clinicopathological parameters and immunohistochemistry, western blotting and real time polymerase chain reaction for Notch4 expression. RESULTS: Our results reveal that the expression of Notch4 was considerably high in oral squamous cell carcinoma lesions compared to normal tissue, whereas in oral verrucous carcinoma, irrespective of the clinicopathological features, complete regulação descendente of Notch4 was observed. CONCLUSIONS:
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Authors | M K Harishankar, A Mathan Mohan, A Vinod Krishnan, Arikketh Devi |
Journal | Brazilian journal of otorhinolaryngology
(Braz J Otorhinolaryngol)
2019 Jan - Feb
Vol. 85
Issue 1
Pg. 11-16
ISSN: 1808-8686 [Electronic] Brazil |
PMID | 29162408
(Publication Type: Journal Article)
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Copyright | Copyright © 2017 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier Editora Ltda. All rights reserved. |
Chemical References |
- Biomarkers, Tumor
- NOTCH4 protein, human
- Receptor, Notch4
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Topics |
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
(analysis)
- Blotting, Western
- Carcinoma, Squamous Cell
(chemistry, diagnosis, pathology)
- Carcinoma, Verrucous
(chemistry, diagnosis, pathology)
- Diagnosis, Differential
- Down-Regulation
- Female
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Mouth Mucosa
(pathology)
- Mouth Neoplasms
(chemistry, diagnosis, pathology)
- Prognosis
- Receptor, Notch4
(analysis)
- Reference Values
- Reverse Transcriptase Polymerase Chain Reaction
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