Abstract | PURPOSE: METHODS: Forty rats were divided into 4 groups. In the sham group, only the hepatic pedicle was mobilized. No other manipulation or treatment was performed. In the other groups, ischemia was achieved by clamping the hepatic pedicle for 60 min. After that, 90 min reperfusion was provided. In the control group, no treatment was given. In the perioperative treatment group, 100 mg/kg erdosteine was administered 2 hours before ischemia induction. In the preoperative treatment group, 100 mg/kg/day erdosteine was administered daily for ten days before the operation. At the end of the procedures, blood and liver samples were obtained for biochemical and histopathological assessment. RESULTS: Treatment with erdosteine ameliorated the histopathological abnormalities when compared with the control group. Furthermore, this treatment significantly decreased the serum liver function test values. It was also found that erdosteine ameliorated the oxidative stress parameters in both the perioperative and preoperative treatment groups. CONCLUSION:
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Authors | Aziz Mutlu Barlas, Kemal Kismet, Serap Erel, Serdar Kuru, Turgut Cavusoglu, Mehmet Senes, Zeynep Adiyaman, Pinar Celepli, Sema Hucumenoglu, Recep Pekcici |
Journal | Acta cirurgica brasileira
(Acta Cir Bras)
Vol. 32
Issue 10
Pg. 796-806
(Oct 2017)
ISSN: 1678-2674 [Electronic] Brazil |
PMID | 29160366
(Publication Type: Journal Article)
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Chemical References |
- Protective Agents
- Thioglycolates
- Thiophenes
- erdosteine
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Topics |
- Animals
- Disease Models, Animal
- Female
- Liver
(blood supply, pathology)
- Protective Agents
(administration & dosage)
- Rats
- Rats, Wistar
- Reperfusion Injury
(drug therapy)
- Thioglycolates
(administration & dosage)
- Thiophenes
(administration & dosage)
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