Abstract | OBJECTIVE: In this study, we evaluated a novel delivery form of boswellic acids (Casperome®) in the management of signs and symptoms associated with ankle sprain grade II due to sport trauma. PATIENTS AND METHODS: In this supplement registry study, 72 otherwise healthy subjects with grade II ankle sprain induced by sport activities were advised to either follow a standard management (SM, 37 subjects) for the condition or the SM with the additional daily intake of 1 tablet containing 250 mg Casperome® (35 subjects). Subjects were allowed to use rescue medications ( ketoprofen tablets, 25 mg/ tablet), and their intake was measured at the end of the management period of 7 days. Each individual was subjected to several non-invasive examinations (self-reported pain at rest and under moderate exercise, range of active and passive movement, presence of local hematomas by ultrasonography) at the following time periods: at inclusion, to evaluate the basal conditions of the subject before the beginning of the study, at day 3 and at the end of the week to evaluate the response differences between the two groups. Additionally, a blood sample from the Casperome® treated subjects (34 out of 35 subjects) was taken at day 7 and analyzed for the systemic concentration of boswellic acids. RESULTS: The 72 individuals recruited in this study spontaneously decided which management to follow, either SM (n=37) or SM+Casperome® (n=35). Supplementation with Casperome® 250 mg/day showed beneficial effects in the reduction of signs and symptoms of ankle sprains evaluated at day 3 and day 7, and was shown to induce measurable plasma level of boswellic acids. Moreover, the supplementary use of Casperome® was well-tolerated and devoid of side effects. CONCLUSIONS: Our pilot registry study showed the effectiveness of Casperome® supplementation in improving recovery after ankle sprain of mild severity (grade II), suggesting a potentially beneficial role in relieving the trauma associated with sport activities and in decreasing the use of rescue drugs.
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Authors | B Feragalli, E Ippolito, M Dugall, M Cacchio, G Belcaro, M R Cesarone, M Abdel-Tawab, A Riva, S Togni, R Eggenhoffner, L Giacomelli |
Journal | European review for medical and pharmacological sciences
(Eur Rev Med Pharmacol Sci)
Vol. 21
Issue 20
Pg. 4726-4732
(Oct 2017)
ISSN: 2284-0729 [Electronic] Italy |
PMID | 29131239
(Publication Type: Journal Article)
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Chemical References |
- Drug Carriers
- Triterpenes
- boswellic acid
- Ketoprofen
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Topics |
- Adult
- Ankle Injuries
(pathology)
- Drug Carriers
(chemistry)
- Female
- Hematoma
(diagnostic imaging)
- Humans
- Ketoprofen
(administration & dosage)
- Male
- Pain
(pathology)
- Pilot Projects
- Registries
- Self Report
- Severity of Illness Index
- Sprains and Strains
(drug therapy, pathology)
- Triterpenes
(blood, therapeutic use)
- Ultrasonography
- Visual Analog Scale
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