Extramural Perineural Invasion in pT3 and pT4 Gastric Carcinomas.

Abstract

BACKGROUND:

Perineural invasion (PNI) is widely studied in malignant tumors, and its prognostic significance is well demonstrated. Most studies have focused on evaluating the mural PNI (mPNI); however, extramural PNI (ePNI) may influence the prognosis in gastric cancer. We evaluated the prognostic value of ePNI compared with mPNI in gastric cancer in this observational comparative cross-sectional study.

METHODS:

Seventy-three pT3 and pT4 gastric carcinomas with PNI were evaluated. Forty-eight (65.7%) were in the mPNI group and the remaining in the ePNI group.

RESULTS:

Clinicopathologic characteristics between the two groups were similar, except for the outcomes. The 5-year disease-specific survival (DSS) rate was 64% for the mPNI group and 50% for the ePNI group (p=.039), a difference that did not remain significant in multivariate analysis. The only independent adverse prognostic factor in multivariate analysis was the presence of lymph node metastasis (hazard ratio, 1.757; 95% confidence interval, 1.082 to 2.854; p=.023).

CONCLUSIONS:

We demonstrated the prognostic effect of ePNI for DSS in surgically resected pT3-pT4 gastric cancer patients. ePNI could be considered in the staging and prognostic systems of gastric cancer to stratify patients with a high risk of recurrence.

• Authors: Alejandro España-Ferrufino, Leonardo S Lino-Silva, Rosa A Salcedo-Hernández
• Journal: Journal of pathology and translational medicine (J Pathol Transl Med) Vol. 52 Issue 2 Pg. 79-84 (Mar 2018) ISSN: 2383-7837 [Print] Korea (South)
• PMID: 29121459 (Publication Type: Journal Article)