PROPHYLACTIC USE OF 15(S)15 METHYL PGF2α BY INTRAMUSCULAR ROUTE FOR CONTROL OF POSTPARTUM BLEEDING - A COMPARATIVE TRIAL WITH METHYLERGOMETRINE.

Abstract

In a multicentre trial (3 centres) the safety and efficacy of an intramuscular injection of 125 µg of 15(S)15 methyl PGF2α (Prostin 15M, Upjohn) was compared with methylergometrine for prophylactic control of bleeding during the third stage of labour. Three hundred patients were recruited for the study - 150 to each treatment group. The duration of the third stage was shorter in the patients (4.4 minutes) treated with Prostin 15M compared to the methylergometrine group (8.6 minutes). Similarly the blood loss during the third stage was reduced by 50% of that observed in the methylergometrine group (72 ml vs 145 ml). Prostin 15M, when used prophylactically was better than methylergometrine in controlling the blood loss during the third stage of labour.

• Authors: P Bhattacharya, Devi Pk, S Jain, Kanthamani Cr, Raghavan Ks
• Journal: Acta obstetricia et gynecologica Scandinavica (Acta Obstet Gynecol Scand) Vol. 67 Issue S145 Pg. 13-15 (Jan 1988) ISSN: 1600-0412 [Electronic] United States
• PMID: 29120046 (Publication Type: Journal Article)
• Copyright: 1988 Acta Obstet Gynecol Scand.