This article was designed to discuss the therapeutic potential of various non-pharmacological and physiotherapeutic methods for the treatment and rehabilitation of the patients presenting with
atopic dermatitis (AD) during the inter-recurrence period of the disease. The particular emphasis is placed on the physical agents most frequently used for the purpose with special reference to the combined
therapy of
atopic dermatitis in the adults and children and to their rehabilitation in the inter-exacerbation periods. In addition, the data on the prospects for the use of various medications intended for tissue- and
organotherapy of the patients suffering from
atopic dermatitis are presented. The main traditional approaches to the management of the patients with
atopic dermatitis under conditions of the spa and health resort facilities are considered based on the original experience of the authors including the application of various modes of
ozone therapy regarded as a physiotherapeutic procedure for the treatment of
atopic dermatitis in the children and adult patients, their rehabilitation, and the prevention of exacerbations of the pathological process based on the external and/or systemic application of the
ozone-
oxygen gaseous mixture. The selected modalities of
ozone therapy used to treat various clinical forms and stages of the
atopic dermatitis differing in severity are described in detail. The data on the influence of
ozone therapy on a variety of pathogenetic factors of
atopic dermatitis are presented as obtained by the investigations into dynamics of the characteristics of immunity, microcirculation, and the levels of
free radical metabolites. The results of the study give evidence of the high effectiveness of
ozone therapy as a method of physiotherapeutic treatment both in the capacity of a component of combined
therapy during the acute phase of
atopic dermatitis and as the means of secondary (post-exposure) prophylaxis of the exacerbations and relapses of this condition based at the medical and preventive treatment facilities of various specialization.