Abstract |
Interferon regulatory factor 1 (IRF1) has been suggested to act as a tumor suppressor in human cancers. However, the clinical significance and biological function of IRF1 in cholangiocarcinoma is poorly understood. In our results, IRF1 mRNA and protein expressions were decreased in cholangiocarcinoma tissues and cell lines compared with paired normal hepatic tissues and intrahepatic bile duct epithelial cell line. IRF1 protein low-expression was associated with tumor stage, tumor size, vascular invasion and metastasis and served as a poor independent prognostic parameter in cholangiocarcinoma patients. Up-regulation of IRF1 expression suppressed cholangiocarcinoma cells proliferation, migration and invasion, and blocked cell cycle progression, but has no effect on apoptosis. In conclusion, IRF1 is low-expressed in cholangiocarcinoma tissues and cell lines, and correlated with malignant status and prognosis in cholangiocarcinoma patients. IRF1 served as tumor suppressor in the regulation of cholangiocarcinoma cells proliferation, cell cycle, migration and invasion.
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Authors | Peiqi Wan, Junhong Zhang, Qiang Du, David A Geller |
Journal | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
(Biomed Pharmacother)
Vol. 97
Pg. 771-777
(Jan 2018)
ISSN: 1950-6007 [Electronic] France |
PMID | 29107934
(Publication Type: Journal Article)
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Copyright | Copyright © 2017 Elsevier Masson SAS. All rights reserved. |
Chemical References |
- IRF1 protein, human
- Interferon Regulatory Factor-1
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Topics |
- Apoptosis
(genetics)
- Bile Duct Neoplasms
(genetics, pathology)
- Bile Ducts, Intrahepatic
(drug effects, metabolism)
- Cell Cycle
(genetics)
- Cell Line
- Cell Line, Tumor
- Cell Movement
(genetics)
- Cell Proliferation
(genetics)
- Cholangiocarcinoma
(genetics, pathology)
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Interferon Regulatory Factor-1
(genetics)
- Male
- Middle Aged
- Neoplasm Metastasis
- Neoplasm Staging
- Prognosis
- Up-Regulation
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