Prognostic factors associated with locally advanced gastric cancer patients treated with neoadjuvant chemotherapy followed by surgical resection.

Abstract

In this retrospective study, we analyzed prognostic factors associated with survival outcomes in 73 locally advanced gastric cancer patients treated with neoadjuvant chemotherapy (NAC) followed by surgical resection. Median disease-free survival (DFS) for 64 patients that received R0 resection was 685 days, whereas median overall survival (OS) for 73 patients was 930 days. Multivariate analysis demonstrated that post-treatment nodal stages (P = 0.002), nervous invasion (P = 0.0492) and serum CA199 levels (P = 0.0398) were independent prognostic factors for DFS. Nodal stages (P = 0.0007), presence of nervous invasion (P = 0.0259) and non-radical resection (P = 0.0165) were independent prognostic factors for OS. These results indicate that post-treatment nodal stages, neural invasion and serum CA199 levels are all associated with poor DFS. Moreover, post-treatment nodal stage, resection type and neural invasion status are independent prognostic factors for OS.

• Authors: Yongkun Sun, Lin Yang, Chengfeng Wang, Dongbing Zhao, Jianqiang Cai, Wenbin Li, Wen Zhang, Jing Huang, Aiping Zhou
• Journal: Oncotarget (Oncotarget) Vol. 8 Issue 43 Pg. 75186-75194 (Sep 26 2017) ISSN: 1949-2553 [Electronic] United States
• PMID: 29088856 (Publication Type: Journal Article)