Abstract | BACKGROUND: METHODS: Data was collected on patients who received 90 mg/m2 doxorubicin as a continuous infusion and 10 gm/m2 ifosfamide for up to 6 cycles as part of a phase II study. Cardiotoxicity was assessed with serial echocardiograms or multigated acquisition scans and serum brain natriuretic peptide and troponin levels. Tumor responses were determined by serial radiographic imaging per RECIST. RESULT: Out of the 48 patients enrolled, no patient developed heart failure symptoms; however, 4 out of the 38 (10%) patients with serial left ventricular ejection fraction assessments developed subclinical cardiotoxicity (asymptomatic drop in LVEF ≥ 10%). Twenty-three patients received all six 72-hour cycles of doxorubicin with a mean cumulative dose of 540 mg/m2. Among these patients, 4% (n = 1) developed subclinical cardiotoxicity. In the advanced disease group (n = 39), patients with a complete or partial response received a higher mean cumulative dose than those with stable disease (p < 0.033). CONCLUSIONS:
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Authors | Raymundo A Quintana, Jose Banchs, Ridhi Gupta, Heather Y Lin, Sean D Raj, Anthony Conley, Vinod Ravi, Dejka Araujo, Robert S Benjamin, Shreyaskumar Patel, Saroj Vadhan-Raj, Neeta Somaiah |
Journal | Sarcoma
(Sarcoma)
Vol. 2017
Pg. 7495914
( 2017)
ISSN: 1357-714X [Print] Egypt |
PMID | 29081684
(Publication Type: Journal Article)
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