Abstract |
To determine the optimal antihypertensive dose of bopindolol, we performed a randomized double-blind study in parallel groups. After 15 days of placebo single-blind, 115 hypertensive patients received daily for 28 days one of 4 doses: 0 mg (placebo), 0.5 mg, 1.0 mg, 2.0 mg. The reduction of supine diastolic blood pressure (BP) did not exhibit the pattern of a dose-effect relationship. The effect of 0.5 mg belonged to the plateau of the dose-effect curve (P = 0.1, analysis of variance). The reduction of heart rate (HR) followed a typical dose-effect curve, with a plateau beginning with 1 mg (P = 0.02). A trend toward an increase in the incidence of side-effects with dosage was observed (P = 0.3). Thus, the optimal antihypertensive dose may be 0.5 mg or less. Previous studies not using parallel randomized groups suggested an antihypertensive dose ranging from 2 to 4 mg. This study confirms that the dose-effect curves of beta blockers on HR and BP are dissociated. The dose-effect curve of HR seems unsuitable for assessing the optimal antihypertensive dose of a beta blocker.
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Authors | P Moleur, J C Peyrieux, J Luciani, D David, J P Boissel |
Journal | Fundamental & clinical pharmacology
(Fundam Clin Pharmacol)
Vol. 2
Issue 5
Pg. 431-40
( 1988)
ISSN: 0767-3981 [Print] England |
PMID | 2906897
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Adrenergic beta-Antagonists
- Pindolol
- bopindolol
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Topics |
- Adrenergic beta-Antagonists
(administration & dosage, adverse effects)
- Blood Pressure
(drug effects)
- Clinical Trials as Topic
- Dose-Response Relationship, Drug
- Double-Blind Method
- Drug Tolerance
- Female
- Heart Rate
(drug effects)
- Humans
- Hypertension
(drug therapy, physiopathology)
- Male
- Middle Aged
- Pindolol
(administration & dosage, adverse effects, analogs & derivatives)
- Random Allocation
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