Mast cell involvement in glucose tolerance impairment caused by chronic mild stress with sleep disturbance.

Abstract

We have developed a chronic mild stress (MS) mouse model by simply rearing mice on a wire net for 3 weeks and investigated the effects of MS on glucose homeostasis and sleep. MS mice showed impaired glucose tolerance and disturbed sleep. One-week treatment with a histamine H1 receptor antagonist (H1RA) ameliorated the glucose intolerance and improved sleep quality in MS mice. MS mice showed an increased number of mast cells in both adipose tissue and the brain. Inhibition of mast cell function ameliorated the impairment in both glucose tolerance and sleep. Together, these findings indicate that mast cells may represent an important pathophysiological mediator in sleep and energy homeostasis.

• Authors: Sachiko Chikahisa, Saki Harada, Noriyuki Shimizu, Tetsuya Shiuchi, Airi Otsuka, Seiji Nishino, Hiroyoshi Séi
• Journal: Scientific reports (Sci Rep) Vol. 7 Issue 1 Pg. 13640 (10 20 2017) ISSN: 2045-2322 [Electronic] England
• PMID: 29057915 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Histamine H1 Antagonists
• Glucose

Topics

• Adipose Tissue (metabolism, pathology)
• Animals
• Brain (drug effects, metabolism, pathology)
• Chronic Disease
• Disease Models, Animal
• Glucose (metabolism)
• Glucose Intolerance (drug therapy, metabolism, pathology)
• Glucose Tolerance Test
• Histamine H1 Antagonists (pharmacology)
• Homeostasis (drug effects, physiology)
• Male
• Mast Cells (drug effects, metabolism, pathology)
• Mice, Inbred ICR
• Mice, Transgenic
• Random Allocation
• Sleep Wake Disorders (drug therapy, metabolism, pathology)
• Stress, Psychological (drug therapy, metabolism, pathology)