Abstract | OBJECTIVE: METHODS: PubMed, EMBASE, Cohrane Library, Ovid, CNKI, and Wanfang Data were searched for randomized controlled trials (RCTs) published up to April 2017. Review Manager 5.3 was used for the Meta analysis. RESULTS: Seven RCTs were included. The Meta analysis showed that after 72 hours and 7 days of treatment, the intravenous immunoglobulin ( IVIG) group had a significantly higher percentage of children who achieved platelet count >20×109/L than the anti-D group (P<0.05). There were no significant differences in platelet count after 24 hours, 72 hours, and 7 days of treatment between the anti-D (50 μg/kg) group and the IVIG group (P>0.05), and there were also no significant differences in platelet count after 24 hours and 7 days of treatment between the 50 μg/kg and 75 μg/kg anti-D groups (P>0.05). The anti-D group had a significantly greater reduction in the hemoglobin level than the IVIG group after treatment, but did not need transfusion. No children in the anti-D group or the IVIG group experienced serious adverse reactions. CONCLUSIONS:
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Authors | Wei Qin, Shao-Ling Huang, Ting-Ting Li |
Journal | Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
(Zhongguo Dang Dai Er Ke Za Zhi)
Vol. 19
Issue 10
Pg. 1070-1076
(Oct 2017)
ISSN: 1008-8830 [Print] China |
PMID | 29046203
(Publication Type: Journal Article, Meta-Analysis)
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Chemical References |
- Immunoglobulins, Intravenous
- Rho(D) Immune Globulin
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Topics |
- Humans
- Immunoglobulins, Intravenous
(adverse effects, therapeutic use)
- Platelet Count
- Purpura, Thrombocytopenic, Idiopathic
(blood, drug therapy)
- Rho(D) Immune Globulin
(adverse effects, therapeutic use)
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