[Pityriasis amiantacea and folliculitis decalvans : An unusual manifestation associated with antitumor necrosis factor-α therapy].

Abstract

We report on a 21-year-old woman with a 3-year history of crusts and erosions on her scalp that had appeared after starting treatment with adalimumab due to Crohn's disease. By clinicopathological correlation pityriasis amiantacea with underlying folliculitis decalvans was diagnosed. Topical and systemic antibiotic treatment showed rapid response. The occurrence of pityriasis amiantacea in folliculitis decalvans associated with tumor necrosis factor (TNF)-α inhibitor therapy is remarkable and highlights the ambivalent role of TNF-α in diseases with immunological dysfunctions in combination with infections.

• Authors: M Zamperetti, B Zelger, R Höpfl
• Journal: Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete (Hautarzt) Vol. 68 Issue 12 Pg. 1007-1010 (Dec 2017) ISSN: 1432-1173 [Electronic] Germany
• Vernacular Title: Pityriasis amiantacea und Folliculitis decalvans : Eine ungewöhnliche Erscheinung, assoziiert mit Anti-Tumor-Nekrose-Faktor-α-Therapie.
• PMID: 29038892 (Publication Type: Case Reports, Journal Article)

Chemical References

• Tumor Necrosis Factor-alpha
• Adalimumab

Topics

• Adalimumab (adverse effects, therapeutic use)
• Alopecia (chemically induced, diagnosis)
• Crohn Disease (drug therapy)
• Diagnosis, Differential
• Female
• Folliculitis (chemically induced, diagnosis, pathology)
• Humans
• Injections, Subcutaneous
• Pityriasis (chemically induced, diagnosis, pathology)
• Scalp (drug effects, pathology)
• Tumor Necrosis Factor-alpha (antagonists & inhibitors)
• Young Adult