HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Piperlongumine suppresses bladder cancer invasion via inhibiting epithelial mesenchymal transition and F-actin reorganization.

Abstract
Piperlongumine (PL), a natural alkaloid isolated from longer pepper plants, is recently found to be a potent selective anti-cancer compound. We first tested its anti-cancer effects on bladder cancer, the fifth most common and aggressive cancer worldwide, to further explore the therapeutic spectrum and molecular mechanisms of PL. PL significantly suppressed bladder cancer cell proliferation, the transition of G2/M phase to next phase, migration/invasion in vitro and bladder cancer growth/development in vivo. PL markedly elevated reactive oxygen species (ROS) and the administration of antioxidants abolished PL induced cell proliferation inhibition, G2/M phase arrest and migration suppression on bladder cancer cells. In vivo studies demonstrated that PL inhibited epithelial mesenchymal transition with profoundly decreased level of Slug, β-catenin, ZEB1 and N-Cadherin. Further, we first reported PL effects on cytoskeleton with prominently reduced lamellipodia formation and decreased F-actin intensity in bladder cancer cells. Taken together, our results first revealed that PL suppressed bladder cancer proliferation and migration in vivo and in vitro, suggesting novel mechanism underlying PL's anti-cancer effect and providing a new anticancer drug strategy for bladder cancer therapy.
AuthorsDi Liu, Xin Yao Qiu, Xi Wu, Dian Xing Hu, Chun Yang Li, Shang Bin Yu, Feng Pan, Xiao Qian Chen
JournalBiochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 494 Issue 1-2 Pg. 165-172 (12 09 2017) ISSN: 1090-2104 [Electronic] United States
PMID29037814 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2017 Elsevier Inc. All rights reserved.
Chemical References
  • Actins
  • Alkaloids
  • Antineoplastic Agents, Phytogenic
  • Dioxolanes
  • Reactive Oxygen Species
  • piperlongumine
Topics
  • Actins (metabolism)
  • Alkaloids (pharmacology)
  • Animals
  • Antineoplastic Agents, Phytogenic (pharmacology)
  • Cell Line, Tumor
  • Cell Movement (drug effects)
  • Cell Proliferation (drug effects)
  • Dioxolanes (pharmacology)
  • Epithelial-Mesenchymal Transition (drug effects)
  • Female
  • Humans
  • Mice
  • Mice, Inbred BALB C
  • Mice, Nude
  • Neoplasm Invasiveness (prevention & control)
  • Reactive Oxygen Species (metabolism)
  • Signal Transduction (drug effects)
  • Urinary Bladder Neoplasms (drug therapy, metabolism, pathology)
  • Xenograft Model Antitumor Assays

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: