Ursolic acid enhances the therapeutic effects of oxaliplatin in colorectal cancer by inhibition of drug resistance.

Abstract	It has been reported that ursolic acid has anti-tumor activity and it enhances the therapeutic effect of oxaliplatin in colorectal cancer (CRC). However, the underlying mechanisms remain unknown. In the present study, the mechanisms of the enhancement of therapeutic effects through use of ursolic acid were investigated. We treated CRC cell lines HCT8 and SW480 with ursolic acid and oxaliplatin and monitored the effects on cell proliferation, apoptosis, reactive oxygen species (ROS) production and drug resistance gene production. We discovered that treatment with a combination of ursolic acid and oxaliplatin resulted in significant inhibition of cell proliferation, significantly increased apoptosis and ROS production, and significant inhibition of drug resistance gene expression. Our study provided evidence that ursolic acid enhances the therapeutic effects of oxaliplatin in colorectal cancer by ROS-mediated inhibition of drug resistance.
Authors	Ye Zhang, Longchang Huang, Haoze Shi, Hang Chen, Jianxin Tao, Renhui Shen, Tong Wang
Journal	Cancer science (Cancer Sci) Vol. 109 Issue 1 Pg. 94-102 (Jan 2018) ISSN: 1349-7006 [Electronic] England
PMID	29034540 (Publication Type: Journal Article)
Copyright	© 2017 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.
Chemical References	Organoplatinum Compounds Reactive Oxygen Species Triterpenes Oxaliplatin
Topics	Animals Antineoplastic Combined Chemotherapy Protocols (administration & dosage, pharmacology) Cell Line, Tumor Cell Proliferation (drug effects) Cell Survival (drug effects) Colorectal Neoplasms (drug therapy, metabolism) Drug Resistance, Neoplasm (genetics) Drug Synergism Humans Mice Organoplatinum Compounds (administration & dosage, pharmacology) Oxaliplatin Reactive Oxygen Species (metabolism) Treatment Outcome Triterpenes (administration & dosage, pharmacology) Xenograft Model Antitumor Assays Ursolic Acid

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