Abstract | Background: Neuroticism is a major risk factor for affective disorders. This personality trait has been hypothesized to associate with synaptic availability of the serotonin transporter, which critically controls serotonergic tone in the brain. However, earlier studies linking neuroticism and serotonin transporter have failed to produce converging findings. Because sex affects both the serotonergic system and the risk that neuroticism poses to the individual, sex may modify the association between neuroticism and serotonin transporter, but this question has not been investigated by previous studies. Methods: Here, we combined data from 4 different positron emission tomography imaging centers to address whether neuroticism is related to serotonin transporter binding in vivo. The data set included serotonin transporter binding potential values from the thalamus and striatum and personality scores from 91 healthy males and 56 healthy females. We specifically tested if the association between neuroticism and serotonin transporter is different in females and males. Results: We found that neuroticism and thalamic serotonin transporter binding potentials were associated in both males and females, but with opposite directionality. Higher neuroticism associated with higher serotonin transporter binding potential in males (standardized beta 0.292, P=.008), whereas in females, higher neuroticism associated with lower serotonin transporter binding potential (standardized beta -0.288, P=.014). Conclusions:
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Authors | Lauri Tuominen, Jouko Miettunen, Dara M Cannon, Wayne C Drevets, Vibe G Frokjaer, Jussi Hirvonen, Masanori Ichise, Peter S Jensen, Liisa Keltikangas-Järvinen, Jacqueline M Klaver, Gitte M Knudsen, Akihiro Takano, Tetsuya Suhara, Jarmo Hietala |
Journal | The international journal of neuropsychopharmacology
(Int J Neuropsychopharmacol)
Vol. 20
Issue 12
Pg. 963-970
(12 01 2017)
ISSN: 1469-5111 [Electronic] England |
PMID | 29020405
(Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Copyright | © The Author 2017. Published by Oxford University Press on behalf of CINP. |
Chemical References |
- Serotonin Plasma Membrane Transport Proteins
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Topics |
- Adolescent
- Adult
- Cerebral Cortex
(diagnostic imaging, metabolism)
- Female
- Humans
- International Cooperation
- Male
- Middle Aged
- Neuroticism
- Positron-Emission Tomography
- Protein Binding
(physiology)
- Regression Analysis
- Serotonin Plasma Membrane Transport Proteins
(metabolism)
- Sex Characteristics
- Young Adult
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