Abstract | BACKGROUND: Secreted clusterin (sCLU), a 75-80 kDa disulfide-linked heterodimeric protein, plays crucial roles in various pathophysiological processes, including lipid transport, tissue remodeling, cell apoptosis and reproduction. Our previous studies demonstrated that sCLU could influence cell apoptosis, proliferation, and invasion of non-small cell lung cancer (NSCLC) cells. METHODS: In this study, clusterin's function in regulating transdifferentiation of NSCLC cells was investigated. In addition, we examined the correlation between clusterin and clinicopathological features of lung cancer. RESULTS: CONCLUSIONS: Our study demonstrated that clusterin could promote EMT and influence transdifferentiation from lung squamous cell carcinoma to lung adenocarcinoma. However, we found that clusterin expression have no correlation with malignance associate clinicopathological data. Our study may help to further elucidate the development and progression of NSCLC, also it may contribute to the research of therapies targeting sCLU.
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Authors | Runsen Jin, Xingshi Chen, Dingpei Han, Xiaoying Luo, Hecheng Li |
Journal | BMC cancer
(BMC Cancer)
Vol. 17
Issue 1
Pg. 661
(Sep 27 2017)
ISSN: 1471-2407 [Electronic] England |
PMID | 28954633
(Publication Type: Journal Article)
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Chemical References |
- CKAP4 protein, human
- Clusterin
- Membrane Proteins
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Topics |
- Adenocarcinoma
(genetics, pathology)
- Aged
- Carcinoma, Non-Small-Cell Lung
(genetics, pathology)
- Carcinoma, Squamous Cell
(genetics, pathology)
- Cell Line, Tumor
- Cell Transdifferentiation
(genetics)
- Clusterin
(genetics)
- Epithelial-Mesenchymal Transition
(genetics)
- Female
- Gene Expression Regulation, Neoplastic
(genetics)
- Humans
- Male
- Membrane Proteins
(genetics)
- Middle Aged
- Neoplasm Invasiveness
(genetics, pathology)
- RNA Interference
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