Estimation of body surface area in the musk shrew ( Suncus murinus): a small animal for testing chemotherapy-induced emesis.

Abstract

Several cancer chemotherapies cause nausea and vomiting, which can be dose-limiting. Musk shrews are used as preclinical models for chemotherapy-induced emesis and for antiemetic effectiveness. Unlike rats and mice, shrews possess a vomiting reflex and demonstrate an emetic profile similar to humans, including acute and delayed phases. As with most animals, dosing of shrews is based on body weight, while translation of such doses to clinically equivalent exposure requires doses based on body surface area. In the current study body surface area in musk shrews was directly assessed to determine the Meeh constant (Km) conversion factor (female = 9.97, male = 9.10), allowing estimation of body surface area based on body weight. These parameters can be used to determine dosing strategies for shrew studies that model human drug exposures, particularly for investigating the emetic liability of cancer chemotherapeutic agents.

• Authors: Julie L Eiseman, Michael Sciullo, Hong Wang, Jan H Beumer, Charles C Horn
• Journal: Laboratory animals (Lab Anim) Vol. 51 Issue 5 Pg. 534-537 (Oct 2017) ISSN: 1758-1117 [Electronic] England
• PMID: 28948895 (Publication Type: Journal Article)

Chemical References

• Antiemetics

Topics

• Animals
• Antiemetics
• Body Surface Area
• Female
• Male
• Mice
• Rats
• Shrews
• Vomiting (chemically induced)