Dietary Manganese Promotes Staphylococcal Infection of the Heart.

Abstract

Diet, and specifically dietary metals, can modify the risk of infection. However, the mechanisms by which manganese (Mn), a common dietary supplement, alters infection remain unexplored. We report that dietary Mn levels dictate the outcome of systemic infections caused by Staphylococcus aureus, a leading cause of bacterial endocarditis. Mice fed a high Mn diet display alterations in Mn levels and localization within infected tissues, and S. aureus virulence and infection of the heart are enhanced. Although the canonical mammalian Mn-sequestering protein calprotectin surrounds staphylococcal heart abscesses, calprotectin is not released into the abscess nidus and does not limit Mn in this organ. Consequently, excess Mn is bioavailable to S. aureus in the heart. Bioavailable Mn is utilized by S. aureus to detoxify reactive oxygen species and protect against neutrophil killing, enhancing fitness within the heart. Therefore, a single dietary modification overwhelms vital host antimicrobial strategies, leading to fatal staphylococcal infection.

• Authors: Lillian J Juttukonda, Evelien T M Berends, Joseph P Zackular, Jessica L Moore, Matthew T Stier, Yaofang Zhang, Jonathan E Schmitz, William N Beavers, Christiaan D Wijers, Benjamin A Gilston, Thomas E Kehl-Fie, James Atkinson, Mary K Washington, R Stokes Peebles, Walter J Chazin, Victor J Torres, Richard M Caprioli, Eric P Skaar
• Journal: Cell host & microbe (Cell Host Microbe) Vol. 22 Issue 4 Pg. 531-542.e8 (Oct 11 2017) ISSN: 1934-6069 [Electronic] United States
• PMID: 28943329 (Publication Type: Journal Article)
• Copyright: Copyright © 2017 Elsevier Inc. All rights reserved.

Chemical References

• Leukocyte L1 Antigen Complex
• Reactive Oxygen Species
• Manganese

Topics

• Abscess
• Animals
• Diet
• Disease Models, Animal
• Endocarditis, Bacterial (microbiology)
• Heart (microbiology, physiopathology)
• Humans
• Leukocyte L1 Antigen Complex (metabolism)
• Liver (microbiology, physiopathology)
• Manganese (analysis, metabolism)
• Mice
• Mice, Congenic
• Mice, Inbred C57BL
• Neutrophils (metabolism)
• Reactive Oxygen Species (metabolism)
• Staphylococcal Infections (microbiology)
• Staphylococcus aureus (metabolism, pathogenicity)