The long-term safety of D-allulose administration in healthy dogs.

Abstract

The safety and biological effects of a long-term dose of D-allulose were evaluated in healthy dogs. For 12 weeks, the dogs were administered D-allulose (0.2 g/kg) or placebo daily. Plasma total cholesterol concentrations in the D-allulose group were significantly lower than those in the control group at and after week 2 (P<0.05). D-Allulose administration did not cause clinical signs or changes in hematological and biochemical levels, except for lipids. D-Allulose administration also did not influence body weight. Plasma glucose and insulin concentrations in the glucose tolerance test, performed one day after the termination of D-allulose administration, were not different between groups, suggesting no cumulative effects of D-allulose on glucose metabolism in healthy dogs. In conclusion, long-term administration of D-allulose caused no harmful effects in dogs.

• Authors: Naohito Nishii, Satoshi Takashima, Yui Kobatake, Masaaki Tokuda, Hitoshi Kitagawa
• Journal: The Journal of veterinary medical science (J Vet Med Sci) Vol. 79 Issue 11 Pg. 1780-1784 (Nov 10 2017) ISSN: 1347-7439 [Electronic] Japan
• PMID: 28924091 (Publication Type: Journal Article)

Chemical References

• Blood Glucose
• Hypoglycemic Agents
• Insulin
• Lipids
• psicose
• Fructose
• Cholesterol

Topics

• Animals
• Blood Glucose (analysis, drug effects)
• Cholesterol (blood)
• Dogs
• Female
• Fructose (adverse effects, pharmacology)
• Glucose Tolerance Test (veterinary)
• Hypoglycemic Agents (adverse effects, pharmacology)
• Insulin (blood)
• Lipids (blood)
• Male