Age-Related Trends in Adults with Community-Onset Bacteremia.

Abstract

To understand the epidemiological variation in bacteremia characteristics among differently aged populations, adults with community-onset bacteremia during a 6-year period were studied in a retrospective cohort. A total of 2,349 bacteremic patients were stratified into four age categories: young adults (18 to 44 years old; 196 patients; 8.3%), adults (45 to 64 years old; 707 patients; 30.1%), the elderly (65 to 84 years old; 1,098 patients; 46.7%), and the oldest old (≥85 years old; 348 patients; 14.8%). Age-related trends in critical illness (a Pitt bacteremia score of ≥4) at bacteremia onset, antibiotic-resistant pathogens (extended-spectrum β-lactamase [ESBL]-producing Escherichia coli, Klebsiella species, and Proteus mirabilis [EKP]; methicillin-resistant Staphylococcus aureus [MRSA]; and levofloxacin nonsusceptible EKP), inappropriate empirical antibiotic therapy (EAT), and 4-week mortality rate were observed. Using a multivariate regression model, critical illness at bacteremia onset (adjusted odds ratio [AOR], 9.03; P < 0.001) and inappropriate EAT (AOR, 2.67; P < 0.001) were the two leading predictors of 4-week mortality. Moreover, ESBL-producing EKP (AOR, 12.94; P < 0.001), MRSA (AOR, 8.66; P < 0.001), and levofloxacin-nonsusceptible EKP (AOR, 4.27; P < 0.001) were linked to inappropriate EAT. In conclusion, among adults with community onset bacteremia, significant positive age-related trends were noted in antibiotic-resistant pathogens and bacteremia severity, which were related to the increasing incidence of inappropriate EAT and 4-week mortality with age. Thus, different empirical antimicrobial regimens should be considered for distinct age groups.

• Authors: Ching-Chi Lee, Jiun-Ling Wang, Chung-Hsun Lee, Yuan-Pin Hung, Ming-Yuan Hong, Chia-Ming Chang, Wen-Chien Ko
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 61 Issue 12 (12 2017) ISSN: 1098-6596 [Electronic] United States
• PMID: 28923864 (Publication Type: Journal Article)
• Copyright: Copyright © 2017 American Society for Microbiology.

Chemical References

• Anti-Bacterial Agents
• Levofloxacin
• beta-Lactamases

Topics

• Adolescent
• Adult
• Age Factors
• Aged
• Aged, 80 and over
• Aging
• Anti-Bacterial Agents (therapeutic use)
• Bacteremia (drug therapy, epidemiology, microbiology)
• Community-Acquired Infections (drug therapy, microbiology)
• Escherichia coli (drug effects)
• Female
• Humans
• Klebsiella pneumoniae (drug effects)
• Levofloxacin (therapeutic use)
• Male
• Methicillin-Resistant Staphylococcus aureus (drug effects)
• Middle Aged
• Proteus mirabilis (drug effects)
• Retrospective Studies
• Young Adult
• beta-Lactamases (metabolism)