Abstract | INTRODUCTION: CASE REPORT: A 28-year-old Romani male was admitted to our hospital for polyarthralgia, polyserositis and fatigability. The patient had high-grade fever, jaundice and generalized lymphadenopathy. Laboratory tests revealed severe mixed hemolytic autoimmune anemia, leukopenia, hepatocytolysis, coagulation abnormalities, hypertriglyceridemia, biological inflammatory syndrome, hyperferritinemia and persistent proteinuria of nephritic pattern. Imaging studies showed pleuropericardial effusion, hepatosplenomegaly and polysynovitis. Additional blood tests revealed hypocomplementemia and positive ANA, anti-dsDNA and anti-Sm antibodies. Haemophagocytosis was not identified either on bone marrow or axillary lymph node biopsy specimens. However, SLE-associated MAS seemed to fit this set-up. High-dose corticotherapy (6.5 g methylprednisolone followed by prednisone, 1.5 mg/kg/day after discharge) and intravenous cyclophosphamide were necessary to induce and sustain remission. CONCLUSION:
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Authors | Delia Tulbă, Marius Balea, Cristian Băicuş |
Journal | Romanian journal of internal medicine = Revue roumaine de medecine interne
(Rom J Intern Med)
Vol. 56
Issue 1
Pg. 67-70
(Mar 01 2018)
ISSN: 1220-4749 [Print] Germany |
PMID | 28918421
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Glucocorticoids
- Immunosuppressive Agents
- Prednisolone
- Methylprednisolone
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Topics |
- Adult
- Diagnosis, Differential
- Drug Resistance
- Glucocorticoids
(administration & dosage)
- Humans
- Immunosuppressive Agents
(administration & dosage)
- Lupus Erythematosus, Systemic
(complications, diagnosis, drug therapy)
- Macrophage Activation Syndrome
(etiology)
- Male
- Methylprednisolone
(administration & dosage)
- Prednisolone
(administration & dosage)
- Remission Induction
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