Abstract | BACKGROUND AND OBJECTIVE: METHODS: A total of 152 subjects were selected from the Korean Obstructive Lung Disease cohort. Their urine samples were assayed for desmosines using liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods. The cohort was divided into emphysema-dominant (n = 80) and non- emphysema dominant- (n = 72) groups according to the CT emphysema index. RESULTS: The level of urinary desmosines was significantly higher in the emphysema-dominant group. Significant differences were also observed between the two groups for body mass index and lung function. Multivariate analysis indicated that a high level of urinary desmosines was a significant independent predictor of emphysema (relative risk: 2.6; 95% CI: 1.11-6.09; P = 0.028). The percentage of frequent exacerbators was significantly higher in the high urinary desmosine group in the first year of follow-up (P = 0.041). The mean number of exacerbations was higher in the high urinary desmosine group, although this difference was not statistically significant (P = 0.067). The changes in emphysema index did not differ between the two urinary desmosine groups over 3 years of follow-up. CONCLUSION: This study indicates that the level of urinary desmosines measured by LC-MS/MS methods is associated with the CT emphysema index. Urinary desmosine can be a useful predictor in identifying frequent exacerbators.
|
Authors | Changhwan Kim, Yousang Ko, Su Hee Kim, Hyun Ju Yoo, Jae Seung Lee, Chin Kook Rhee, Jin Hwa Lee, Ji-Hyun Lee, Tae-Hyung Kim, Seong Yong Lim, Kwang Ha Yoo, Joon Beom Seo, Yeon-Mok Oh, Sang-Do Lee, Yong Bum Park |
Journal | Respirology (Carlton, Vic.)
(Respirology)
Vol. 23
Issue 2
Pg. 176-181
(02 2018)
ISSN: 1440-1843 [Electronic] Australia |
PMID | 28905464
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | © 2017 Asian Pacific Society of Respirology. |
Chemical References |
- Biomarkers
- Desmosine
- Isodesmosine
|
Topics |
- Aged
- Biomarkers
(urine)
- Cohort Studies
- Desmosine
(urine)
- Female
- Humans
- Isodesmosine
(urine)
- Male
- Middle Aged
- Pulmonary Disease, Chronic Obstructive
(complications, diagnostic imaging, urine)
- Pulmonary Emphysema
(diagnostic imaging, etiology, urine)
- Severity of Illness Index
- Tomography, X-Ray Computed
|