Endoluminal weight loss and metabolic therapies: current and future techniques.

Abstract

Obesity is a public health epidemic associated with a number of comorbidities, most notably type 2 diabetes and hypertension, as well as elevated all-cause mortality. The treatment for obesity and its associated comorbidities has most recently expanded into the field of bariatric endoscopy. This field bridges a gap between lifestyle counseling with or without pharmaceutical treatment and the most effective treatment of obesity, bariatric surgery. Because of its minimally invasive nature, bariatric endoscopic therapy has the potential to appeal to the large sector of the obese population that resists surgery, as well as those early in the onset of obesity. To date, five endoscopic devices have been approved by the U.S. Food and Drug Administration for the treatment of obesity, and many more are in development, undergoing clinical trials, or being used around the world. Here, we present the current state of the field, highlight recent developments, and describe the clinical outcomes of these minimally invasive procedures in terms of weight loss, improvement in metabolic profile, and reduction in comorbidities.

• Authors: Christine Hill, Mouen A Khashab, Anthony N Kalloo, Vivek Kumbhari
• Journal: Annals of the New York Academy of Sciences (Ann N Y Acad Sci) Vol. 1411 Issue 1 Pg. 36-52 (01 2018) ISSN: 1749-6632 [Electronic] United States
• PMID: 28884820 (Publication Type: Journal Article, Review)
• Copyright: © 2017 New York Academy of Sciences.

Chemical References

• Hypoglycemic Agents
• Botulinum Toxins, Type A

Topics

• Bariatric Surgery (instrumentation, methods)
• Botulinum Toxins, Type A (pharmacology, therapeutic use)
• Clinical Trials as Topic
• Combined Modality Therapy
• Comorbidity
• Diabetes Mellitus, Type 2 (drug therapy, surgery)
• Duodenum (surgery)
• Endoscopy (methods)
• Equipment Design
• Foreign-Body Migration (etiology)
• Gastric Emptying (drug effects)
• Humans
• Hypoglycemic Agents (therapeutic use)
• Intraoperative Complications (etiology)
• Magnets
• Minimally Invasive Surgical Procedures
• Multicenter Studies as Topic
• Obesity (epidemiology, surgery)
• Postoperative Complications (etiology)
• Recurrence
• Suction
• Weight Loss