Relationship of very low serum 25-hydroxyvitamin D3 levels with long-term survival in a large cohort of colorectal cancer patients from Germany.

Abstract

To investigate the association of serum 25-hydroxyvitamin D (25(OH)D3) with survival in a large prospective cohort study of colorectal cancer (CRC) patients. The study population consisted of 2,910 patients diagnosed with CRC between 2003 and 2010 who participated in the DACHS study, a multicenter study from Germany with comprehensive long-term follow-up. 25(OH)D3 was determined in serum samples collected shortly after cancer diagnosis by High Performance Liquid Chromatography-Electro Spray Ionization-Mass Spectrometry. Analyses of survival outcomes were performed using Cox regression with comprehensive adjustment for relevant confounders. The majority (59%) of CRC patients were vitamin D deficient (serum 25(OH)D3 levels <30 nmol/L). During a median follow-up of 4.8 years, 787 deaths occurred, 573 of which were due to CRC. Compared to patients in the highest 25(OH)D3 quintile (>45.20 nmol/L), those in the lowest 25(OH)D3 quintile (<11.83 nmol/L) had a strongly increased mortality. Adjusted hazard ratios (95% Confidence Interval) were 1.78 (1.39-2.27), 1.65 (1.24-2.21), 1.32 (1.03-1.71) and 1.48 (1.18-1.85) for all-cause mortality, CRC-specific mortality, recurrence-free and disease-free survival, respectively. Subgroup analyses did not show any significant effect modification across strata defined by sex, age, stage, body mass index, or the late entry. Dose-response analyses showed a strong inverse relationship between serum 25(OH)D3 levels and survival endpoints at 25(OH)D3 levels <30 nmol/L, and no association with mortality at higher 25(OH)D3 levels. Vitamin D deficiency is highly prevalent in CRC patients and a strong independent predictor of poor prognosis. The possibility of enhancing CRC prognosis by vitamin D supplementation, ideally combined with outdoor physical activity, should be evaluated by randomized controlled trials focusing on patients with vitamin D deficiency.

• Authors: Haifa Maalmi, Viola Walter, Lina Jansen, Jenny Chang-Claude, Robert W Owen, Alexis Ulrich, Ben Schöttker, Michael Hoffmeister, Hermann Brenner
• Journal: European journal of epidemiology (Eur J Epidemiol) Vol. 32 Issue 11 Pg. 961-971 (11 2017) ISSN: 1573-7284 [Electronic] Netherlands
• PMID: 28884317 (Publication Type: Journal Article)

Chemical References

• Vitamin D
• 25-hydroxyvitamin D
• Calcifediol

Topics

• Adult
• Aged
• Calcifediol (blood)
• Colorectal Neoplasms (blood, epidemiology)
• Dietary Supplements
• Female
• Germany (epidemiology)
• Humans
• Male
• Middle Aged
• Prospective Studies
• Risk Factors
• Survivors
• Vitamin D (analogs & derivatives)
• Vitamin D Deficiency (blood, epidemiology)