There have been several reports that
steroid administration is effective at preventing
strictures after endoscopic submucosal dissection (ESD). However, adverse events after
steroid use are of great concern. We have reported that shielding with a
polyglycolic acid (
PGA) sheet and
fibrin glue can be useful for prevention of
stricture after ESD. We conducted a retrospective analysis of efficiency of shielding with a
PGA sheet and
fibrin glue for prevention of
esophageal stricture compared with intralesional
steroid injection. ESD was performed on a total of 489 lesions in 400 patients for superficial
esophageal cancer from January 2012 to July 2016. Of these, 39 lesions were enrolled in the study group (
PGA sheet and
fibrin glue) and 31 lesions were enrolled in the control group. The incidence of postoperative
stricture at 6 weeks and the number of sessions of endoscopic balloon dilatation (EBD) required to resolve any
strictures were evaluated. The post-ESD
stricture rate was 9.1% in the study group (3/33 patients), which was not significantly lower than the
stricture rate of 10.3% in the historical control group (3/29 patients; p = 1.00). The mean number of EBD was 0.057 ± 0.24 in the study group and 1.9 ± 5.1 in the control group, which was not significant (P = 0.95).
PGA sheet and
fibrin glue appear to be a promising option for the prevention of
esophageal stricture similar to the effect of intralesional
steroid injection.