Abstract | BACKGROUND: METHODS: The nociception was assessed by measuring the incidence of foot withdrawal in response to mechanical indentation in rats (n = 6). Cell signaling was assayed using western blotting (n = 6) and immunohistochemistry (n = 5). The astrocyte cell line C8-D1A was cultured to investigate the in vitro effects. RESULTS:
TMP significantly attenuated the maintenance of chronic constrictive injury (CCI)-induced neuropathic pain, inhibited the activation of astrocytes, and decreased the expression of MMP-2/9. Furthermore, our results indicated that TMP could selectively suppress JNK activity but had no notable effects on ERK and p38. Our study also revealed that the effect of TMP may be dependent on the inhibition of TAK1. CONCLUSIONS:
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Authors | Lai Jiang, Cai-Long Pan, Chao-Yu Wang, Bing-Qian Liu, Yuan Han, Liang Hu, Lei Liu, Yang Yang, Jun-Wei Qu, Wen-Tao Liu |
Journal | Journal of neuroinflammation
(J Neuroinflammation)
Vol. 14
Issue 1
Pg. 174
(Aug 31 2017)
ISSN: 1742-2094 [Electronic] England |
PMID | 28859670
(Publication Type: Journal Article)
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Chemical References |
- Matrix Metalloproteinase Inhibitors
- Pyrazines
- Vasodilator Agents
- Matrix Metalloproteinase 2
- Mmp2 protein, rat
- Matrix Metalloproteinase 9
- Mmp9 protein, rat
- tetramethylpyrazine
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Topics |
- Animals
- Astrocytes
(drug effects, enzymology)
- Cells, Cultured
- Injections, Spinal
- MAP Kinase Signaling System
(drug effects, physiology)
- Male
- Matrix Metalloproteinase 2
(metabolism)
- Matrix Metalloproteinase 9
(metabolism)
- Matrix Metalloproteinase Inhibitors
(administration & dosage)
- Neuralgia
(drug therapy, enzymology)
- Pyrazines
(administration & dosage)
- Rats
- Rats, Sprague-Dawley
- Vasodilator Agents
(administration & dosage)
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