Association Between MGMT Promoter Methylation and Breast Cancer: a Meta-Analysis.

Abstract

BACKGROUND/AIMS:

Numerous studies have suggested that the promoter methylation status of O6-methylguanine-DNA methyltransferase (MGMT) is significantly associated with breast cancer. However, these studies have not demonstrated consistent results.

METHODS:

To obtain more accurate results for this possible association, we performed a meta-analysis-based study using the relevant data. A total of 14 articles were included in this meta-analysis.

RESULTS:

Our study showed that the frequency of MGMT promoter methylation was significantly higher in patients with breast cancer than non-breast cancer subjects with an Odds Ratio (OR) of 4.47, a 95% Confidence Interval (CI) ranging between 1.95 - 10.25 and a P value of 0.0004. Moreover, MGMT methylation was significantly associated with the negative expression of the MGMT protein (OR = 4.65, 95%CI = 2.66 - 8.12, P < 0.00001), Oestrogen Receptor (ER)-negative tumours (OR = 1.79, 95%CI = 1.09 - 2.93, P = 0.02), postmenopausal status (OR =1.84, 95%CI = 1.18 - 2.87, P = 0.007) and histological grade III tumours (OR = 2.49, 95%CI = 1.53 - 4.07, P = 0.0003) in breast cancer patients. However, breast cancer was not significantly correlated with lymph node metastasis (OR = 1.19, 95%CI = 0.83 - 1.70, P = 0.35), Progesterone Receptor (PR) status (OR = 1.08, 95%CI = 0.58 - 2.00, P = 0.81), Human epidermal growth factor receptor - 2（HER-2/neu）status (OR = 1.01, 95%CI = 0.65 - 1.57, P = 0.97), P53 mutation (OR = 1.30, 95%CI = 0.76 - 2.21, P = 0.34) and age > 50 (OR = 1.07, 95%CI = 0.46 - 2.51, P = 0.88).

CONCLUSIONS:

Our study suggests that MGMT promoter methylation may be an early biomarker for the diagnosis of breast cancer.

• Authors: Nairui An, Yu Shi, Peng Ye, Zhongya Pan, Xinghua Long
• Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology (Cell Physiol Biochem) Vol. 42 Issue 6 Pg. 2430-2440 ( 2017) ISSN: 1421-9778 [Electronic] Germany
• PMID: 28848211 (Publication Type: Journal Article, Meta-Analysis)
• Copyright: © 2017 The Author(s). Published by S. Karger AG, Basel.

Chemical References

• Biomarkers, Tumor
• Receptors, Progesterone
• TP53 protein, human
• Tumor Suppressor Protein p53
• Tumor Suppressor Proteins
• DNA Modification Methylases
• MGMT protein, human
• Receptor, ErbB-2
• DNA Repair Enzymes

Topics

• Biomarkers, Tumor (genetics, metabolism)
• Breast Neoplasms (diagnosis, genetics, pathology)
• DNA Methylation
• DNA Modification Methylases (genetics, metabolism)
• DNA Repair Enzymes (genetics, metabolism)
• Databases, Factual
• Female
• Humans
• Lymphatic Metastasis
• Neoplasm Grading
• Odds Ratio
• Postmenopause
• Promoter Regions, Genetic
• Receptor, ErbB-2 (genetics, metabolism)
• Receptors, Progesterone (genetics, metabolism)
• Tumor Suppressor Protein p53 (genetics, metabolism)
• Tumor Suppressor Proteins (genetics, metabolism)