[Expression profile of long non-coding RNA in non-alcoholic fatty liver disease].

Abstract

OBJECTIVE:

To analyze the characteristics of long non-coding RNA (lncRNA) expression in non-alcoholic fatty liver disease (NAFLD).
 Methods: lncRNA-mRNA microarray was conducted on the liver tissue samples from 10 patients with simple gallbladder stone (5 NAFLD liver samples and 5 normal liver samples), and the differentially expressed lncRNA was analyzed by bioinformatics technology.
 Results: Compared with the normal liver samples, there were abnormal expression of 1 735 lncRNAs and 1 485 mRNAs in NAFLD liver samples. Among them, 535 lncRNAs and 760 mRNAs were up-regulated, 1 200 lncRNAs and 725 mRNAs were down-regulated.
 Conclusion: Compared with normal liver, the expression of lncRNA in NAFLD tissues is obviously abnormal. These lncRNAs may play an important role in the occurrence and development of NAFLD.

• Authors: Chuanzheng Sun, Feizhou Huang, Wenguang Yan, Huaizheng Liu, Changfa Wang
• Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences (Zhong Nan Da Xue Xue Bao Yi Xue Ban) Vol. 42 Issue 7 Pg. 741-748 (Jul 28 2017) ISSN: 1672-7347 [Print] China
• PMID: 28844995 (Publication Type: Journal Article)

Chemical References

• RNA, Long Noncoding
• RNA, Messenger

Topics

• Gallbladder Diseases (physiopathology)
• Gene Expression Profiling
• Gene Expression Regulation
• Humans
• Non-alcoholic Fatty Liver Disease (physiopathology)
• RNA, Long Noncoding (genetics)
• RNA, Messenger (genetics)