Abstract | BACKGROUND: METHODS: The occurrence of a major cardiovascular event (MCVE) was assessed using the data from the Treating to New Targets ( TNT) and Incremental Decrease in End points through Aggressive Lipid lowering (IDEAL) trials. RESULTS: Pooled analysis of these two data sets showed that both directly-measured apoB (HR per 1-SD (95% CI): 1.16 (1.11-1.21), P < 0.001) and apoB estimated from the eq. (HR per 1-SD (95% CI): 1.14 (1.09-1.19), P < 0.001) were significantly associated with the development of a future MCVE. Prediction of MCVEs by the apoB eq. (C statistic 0.650) was nearly identical to that of directly-measured apoB (0.651). In addition, the net reclassification indices indicated no difference in the prediction of MCVEs between models including the apoB equation and directly-measured apoB (1% (-1.3-4.0), P = 0.31). CONCLUSIONS: Our equation to predict apoB levels showed MCVE risk prediction comparable to directly-measured apoB in high risk patients with previous coronary heart disease.
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Authors | You-Cheol Hwang, Hong-Yup Ahn, Ki Hoon Han, Sung-Woo Park, Cheol-Young Park |
Journal | Lipids in health and disease
(Lipids Health Dis)
Vol. 16
Issue 1
Pg. 158
(Aug 22 2017)
ISSN: 1476-511X [Electronic] England |
PMID | 28830468
(Publication Type: Journal Article)
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Chemical References |
- Apolipoproteins B
- Biomarkers
- Cholesterol, HDL
- Triglycerides
- Cholesterol
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Topics |
- Aged
- Apolipoproteins B
(blood)
- Biomarkers
(blood)
- Cardiovascular Diseases
(blood, pathology)
- Cholesterol
(blood)
- Cholesterol, HDL
(blood)
- Female
- Humans
- Male
- Middle Aged
- Risk Factors
- Triglycerides
(blood)
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