Increased serum levels of fetuin B in patients with coronary artery disease.

Abstract

BACKGROUND:

Recent evidence indicates a pivotal role for fetuin B, one of the cystatin superfamily of cysteine protease inhibitors, in the pathogenesis of metabolic diseases. This study investigated whether serum fetuin B levels are associated with the presence of coronary artery disease.

METHODS:

Serum fetuin B levels were assessed in 87 patients with coronary artery disease (41 with acute coronary syndromes and 46 with stable angina pectoris) and 87 healthy controls using an enzyme-linked immunosorbent assay. The association of serum fetuin B levels with cardiac risk factors was analyzed.

RESULTS:

Serum fetuin B levels were significantly higher in patients with coronary artery disease than those in healthy controls (90.7 ± 32.1 vs. 110.0 ± 32.7 μg/ml, P < 0.001), extremely elevated in group with acute coronary syndromes (115.0 ± 35.2 μg/ml). Pearson correlation analysis showed that serum fetuin B levels were positively associated with the levels of total cholesterol (r = 0.276, P < 0.001), low-density lipoprotein cholesterol (r = 0.363, P < 0.001), and fasting blood glucose (r = 0.159, P < 0.05). In addition, multiple logistic regression analyses revealed that fetuin B was independently associated with the presence of coronary artery disease (OR, 1.019; 95% CI, 1.009 to 1.029; P < 0.001) and acute coronary syndromes (OR, 1.017; 95% CI, 1.006 to 1.028; P < 0.01).

CONCLUSIONS:

Our data revealed that high fetuin B levels are associated with the presence of coronary artery disease and acute coronary syndromes, and that fetuin B may serve as a potential biomarker for coronary artery disease.

• Authors: Kefu Zhu, Yuming Wang, Pengqin Shu, Qinyi Zhou, Jinzhou Zhu, Wenjing Zhou, Changqing Du, Chenkai Xu, Xiaowei Liu, Lijiang Tang
• Journal: Endocrine (Endocrine) Vol. 58 Issue 1 Pg. 97-105 (Oct 2017) ISSN: 1559-0100 [Electronic] United States
• PMID: 28822077 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• Blood Glucose
• Cholesterol, HDL
• Cholesterol, LDL
• FETUB protein, human
• Fetuin-B
• Cholesterol

Topics

• Acute Coronary Syndrome (blood)
• Aged
• Aged, 80 and over
• Angina Pectoris (metabolism)
• Biomarkers (blood)
• Blood Glucose (metabolism)
• Cholesterol (blood)
• Cholesterol, HDL (blood)
• Cholesterol, LDL (blood)
• Coronary Artery Disease (blood)
• Female
• Fetuin-B (analysis)
• Humans
• Male
• Middle Aged
• ROC Curve
• Risk Factors