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Rethinking Schistosomiasis Vaccine Development: Synthetic Vesicles.

Abstract
There is currently no vaccine against schistosomiasis. With few Schistosoma vaccine candidates in clinical trials, unexplored antigens from the vulnerable schistosomulum should be considered as possible vaccine candidates. In addition, we suggest developing synthetic vesicles as a new delivery vehicle and adjuvant for immunoprophylactic schistosomula vaccine candidates.
AuthorsMoses Egesa, Karl F Hoffmann, Cornelis H Hokke, Maria Yazdanbakhsh, Stephen Cose
JournalTrends in parasitology (Trends Parasitol) Vol. 33 Issue 12 Pg. 918-921 (12 2017) ISSN: 1471-5007 [Electronic] England
PMID28818406 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2017 Elsevier Ltd. All rights reserved.
Chemical References
  • Antigens, Helminth
  • Vaccines
Topics
  • Animals
  • Antigens, Helminth (immunology)
  • Humans
  • Schistosoma mansoni (metabolism)
  • Schistosomiasis (prevention & control)
  • Vaccines (administration & dosage)

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