Association between LRP1 C766T polymorphism and Alzheimer's disease susceptibility: a meta-analysis.

Abstract

Low density lipoprotein receptor-related protein 1 (LRP1) C766T polymorphism (rs1799986) has been extensively investigated for Alzheimer's disease (AD) susceptibility. However, results in different studies have been contradictory. Therefore, we conducted a meta-analysis containing 6455 AD cases and 6304 controls from 26 independent case-control studies to determine whether there was an association between the LRP1 C766T polymorphism and AD susceptibility. The combined analysis showed that there was no significant association between LRP1 C766T polymorphism and AD susceptibility (TT + CT versus CC: OR = 0.920, 95% CI = 0.817-1.037, P = 0.172). In subgroup analysis, significant decreased AD susceptibility was found among Asian population in allele model (T versus C: OR = 0.786, 95% CI = 0.635-0.974, P = 0.028) and dominant model (TT + CT versus CC: OR = 0.800, 95% CI = 0.647-0.990, P = 0.040). Moreover, T allele of LRP1 C766T was statistically associated with late onset of AD (LOAD) (T versus C: OR = 0.858, 95% CI = 0.748-0.985, P = 0.029; TT + CT versus CC: OR = 0.871, 95% CI = 0.763-0.994, P = 0.040). In conclusion, our meta-analysis suggested that LRP1 C766T polymorphism was associated with lower risk of AD in Asian, and could reduce LOAD risk especially. Considering some limitations of our meta-analysis, further large-scale studies should be done to reach a more comprehensive understanding.

• Authors: Yun Wang, Shengyuan Liu, Jingjing Wang, Jie Zhang, Yaqiong Hua, Hua Li, Huibiao Tan, Bin Kuai, Biao Wang, Sitong Sheng
• Journal: Scientific reports (Sci Rep) Vol. 7 Issue 1 Pg. 8435 (08 16 2017) ISSN: 2045-2322 [Electronic] England
• PMID: 28814781 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)

Chemical References

• LRP1 protein, human
• Low Density Lipoprotein Receptor-Related Protein-1

Topics

• Alleles
• Alzheimer Disease (ethnology, genetics, pathology)
• Asian People (genetics)
• Case-Control Studies
• Gene Frequency
• Genetic Predisposition to Disease (ethnology, genetics)
• Genotype
• Humans
• Low Density Lipoprotein Receptor-Related Protein-1 (genetics)
• Polymorphism, Single Nucleotide
• Risk Factors