The inflammatory process plays a central role in the development and progression of numerous pathological situations, such as
inflammatory bowel disease (IBD), autoimmune and
neurodegenerative diseases,
metabolic syndrome, and cardiovascular disorders. IBDs involve
inflammation of the gastrointestinal area and mainly comprise
Crohn's disease (CD) and
ulcerative colitis (UC). Both pathological situations usually involve recurring or bloody
diarrhea,
pain,
fatigue and
weight loss. There is at present no pharmacological cure for CD or UC. However, surgery may be curative for UC patients. The prescribed treatment aims to ameliorate the symptoms and prevent and/or delay new painful episodes.
Flavonoid compounds are a large family of hydroxylated polyphenolic molecules abundant in plants, including vegetables and fruits which are the major dietary sources of these compounds for humans, together with wine and
tea.
Flavonoids are becoming very popular because they have many health-promoting and disease-preventive effects. Most interest has been directed towards the
antioxidant activity of
flavonoids, evidencing a remarkable
free-radical scavenging capacity. However, accumulating evidence suggests that
flavonoids have many other biological properties, including anti-inflammatory,
antiviral, anticancer, and neuroprotective activities through different mechanisms of action. The present review analyzes the available data about the different types of
flavonoids and their potential effectiveness as adjuvant
therapy of IBDs.