[A study of combination treatment with nacom (levodopa + carbodope) and citicoline in the model of Parkinson disease in rats].

Abstract

AIM:

To evaluate the efficacy of the combined use of citicoline (neipilept) and levodopa/carbidopa (nakom) in the rotenone model of Parkinson's disease in rats.

MATERIAL AND METHODS:

Rotenone was administrated during 14 days in dose 2 mg/kg/day subcutaneously. The duration of treatment was 7 days, intragastrically. Alteration of locomotor behavior components, muscular rigidity in resistance to passive flexion in the ankle joint and signs of extrapyramidal disorders were assessed.

RESULTS AND CONCLUSION:

Combined therapy led to the decrease in muscle rigidity (the decrease of gibbosity in resistance to passive flexion in the ankle joint). There was a decrease in oligokinesia that emerged in higher vertical and horizontal locomotor activity of experimental animals, decrease in the time of head turning during climbing down the pole and total time of climbing down the pole. The combination of drugs had a more pronounced therapeutic effect on extrapyramidal disorders compared to monotherapy.

• Authors: V A Kashkin, E V Shekunova, M N Makarova, V G Makarov
• Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (Zh Nevrol Psikhiatr Im S S Korsakova) 2017 Vol. 117 Issue 7 Pg. 59-63 ISSN: 1997-7298 [Print] Russia (Federation)
• Vernacular Title: Éffektivnost' kombinirovannogo primeneniia levodopy i karbidopy s tsitikolinom pri éksperimental'noĭ modeli bolezni Parkinsona.
• PMID: 28805762 (Publication Type: Journal Article)

Chemical References

• Antiparkinson Agents
• Drug Combinations
• Nootropic Agents
• carbidopa, levodopa drug combination
• Levodopa
• Cytidine Diphosphate Choline
• Carbidopa

Topics

• Animals
• Antiparkinson Agents (therapeutic use)
• Carbidopa (therapeutic use)
• Cytidine Diphosphate Choline (therapeutic use)
• Disease Models, Animal
• Drug Combinations
• Drug Therapy, Combination
• Levodopa (therapeutic use)
• Male
• Nootropic Agents (therapeutic use)
• Parkinson Disease (drug therapy)
• Rats
• Rats, Wistar