GFAP in early multiple sclerosis: A biomarker for inflammation.

Abstract

OBJECTIVE:

The role of Glial Fibrillic Acidic Protein (GFAP) as a potential biomarker for relapsing-remitting multiple sclerosis (RRMS) and clinically isolated syndrome (CIS) has been controversially discussed. The aim was to characterize the added value of GFAP levels in the CSF of RRMS and CIS patients in correlation with MRI lesion load.

MATERIALS & METHODS:

GFAP levels in the CSF from 18 patients with RRMS, 8 patients with CIS and 35 controls were analyzed together with MRI data for acute and chronic inflammatory lesion load.

RESULTS:

GFAP levels of patients vs. controls were higher (p=0.005), while there was no difference between GFAP levels in RRMS and CIS. There was no correlation between the number of supra- or infratentorial gadolinium enhancing lesions and GFAP levels, while there was a correlation between GFAP levels with infratentorial chronic inflammatory lesion load (p=0.0035). Most importantly, a highly significant correlation could be observed between GFAP levels and the intensity of gadolinium-enhancement as a parameter for the acute activity of inflammatory processes (p=0.0002).

CONCLUSIONS:

GFAP seems to be a useful biomarker for highly active acute inflammation in patients with RRMS as well as with CIS.

• Authors: Rebecca Kassubek, Martin Gorges, Michael Schocke, Viktoria A M Hagenston, André Huss, Albert C Ludolph, Jan Kassubek, Hayrettin Tumani
• Journal: Neuroscience letters (Neurosci Lett) Vol. 657 Pg. 166-170 (Sep 14 2017) ISSN: 1872-7972 [Electronic] Ireland
• PMID: 28802830 (Publication Type: Journal Article)
• Copyright: Copyright © 2017 Elsevier B.V. All rights reserved.

Chemical References

• Biomarkers
• Glial Fibrillary Acidic Protein

Topics

• Adolescent
• Adult
• Biomarkers (cerebrospinal fluid)
• Brain (diagnostic imaging)
• Female
• Glial Fibrillary Acidic Protein (cerebrospinal fluid)
• Humans
• Inflammation (cerebrospinal fluid)
• Male
• Middle Aged
• Multiple Sclerosis, Relapsing-Remitting (cerebrospinal fluid, diagnostic imaging)
• Young Adult