Long non-coding RNAs and prostate cancer.

Abstract

Long non-coding RNAs (lncRNAs) are RNA transcripts larger than 200 nucleotides that do not code for proteins the aberrant expression of which has been documented in various types of cancer, including prostate cancer. Lack of appropriate sensitive and specific biomarkers for prostate cancer has led to overdiagnosis and overtreatment, making lncRNAs promising novel biomarkers as well as therapeutic targets for the disease. The present review attempts to summarize the current knowledge of lncRNA expression patterns and mechanisms in prostate cancer, which contribute to carcinogenesis. In particular, we focused on lncRNAs regulated by androgen receptor and expressed in castration-resistant prostate cancer.

• Authors: Aya Misawa, Ken-Ichi Takayama, Satoshi Inoue
• Journal: Cancer science (Cancer Sci) Vol. 108 Issue 11 Pg. 2107-2114 (Nov 2017) ISSN: 1349-7006 [Electronic] England
• PMID: 28796922 (Publication Type: Journal Article, Review)
• Copyright: © 2017 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

Chemical References

• Biomarkers, Tumor
• RNA, Long Noncoding

Topics

• Biomarkers, Tumor (genetics)
• Gene Expression Regulation, Neoplastic
• Humans
• Male
• Medical Overuse
• Prostatic Neoplasms (diagnosis, genetics, pathology)
• RNA, Long Noncoding (genetics)