Abstract | OBJECTIVE: MATERIALS AND METHODS: Medline, Web of Science, Embase, Cochrane Library, CBM and CNKI databases were searched to identify all the relevant articles published prior to 16 December 2016. Grey literature was also searched. Randomized controlled human clinical trials in which non- fluoride agents were delivered by any method were considered. RESULTS: CONCLUSIONS: A study at low risk of bias indicated that daily use of xylitol wipes is a useful adjunct for caries control in young children, however, this conclusion should be interpreted with caution as this study had a very limited sample size. Chlorhexidine and CPP-ACP may be more effective than a placebo in managing caries in primary dentition, but their effectiveness is borderline when compared with fluoride. Arginine-containing mint confection and 0.3% triclosan varnish were found to reduce caries development in primary teeth but the evidence was at high risk of bias. High quality randomized controlled trials are needed in order to make a conclusive recommendation.
|
Authors | Yu Wang, Jialing Li, Weibin Sun, Huang Li, Richard D Cannon, Li Mei |
Journal | PloS one
(PLoS One)
Vol. 12
Issue 8
Pg. e0182221
( 2017)
ISSN: 1932-6203 [Electronic] United States |
PMID | 28787448
(Publication Type: Journal Article, Review, Systematic Review)
|
Chemical References |
|
Topics |
- Cariostatic Agents
(therapeutic use)
- Dental Caries
(prevention & control)
- Humans
- Randomized Controlled Trials as Topic
- Tooth, Deciduous
(drug effects)
|