The present study explores the
pain attenuating effect of
perampanel,
AMPA receptor antagonist, in chronic constriction injury-induced
neuropathic pain. Chronic Constriction Injury was performed by putting four loose
ligatures around the sciatic nerve.
Pain was assessed by determining
mechanical hyperalgesia, cold
allodynia and heat
hyperalgesia on 7th and 14th day post surgery.
Perampanel (3mg and 6mg/kg, p.o.) was administered 30min before
pain assessment test on 14th day post-surgery. CCI led to significant development of
pain and peak symptoms were observed on 14th day.
Perampanel significantly attenuated CCI-induced
mechanical hyperalgesia, cold
allodynia and heat
hyperalgesia, at different time intervals 30, 60, 90, 120min, with more substantial effect observed at dose of 6mg/kgNaloxone was administered in CCI subjected rats before
perampanel treatment to explore the potential role of
opioids in anti-nociceptive effects of
perampanel.
Naloxone decreased the
pain attenuating effects of
perampanel significantly, indicating a critical role of
opioid system in anti-nociceptive potential of
perampanel.
Perampanel has
pain attenuating potential in CCI-induced
neuropathic pain, which may be due to partly mediated through the
opioid system.