Abstract | OBJECTIVE: METHODS: A nationwide cross-sectional study was conducted to examine the relationship between serum ferritin and IR and MetS in 2734 postmenopausal women using data from the 2010-2012 Korean National Health and Nutrition Examination Survey. The odds ratios ( ORs) and 95% confidence intervals (CIs) for insulin resistance (HOMA-IR≥75th percentile, 3.04) and MetS were calculated using multiple logistic regression analyses across serum ferritin quartiles (Q1,≤36.25; Q2, 36.56-56.56; Q3, 56.57-85.98; and Q4≥85.99ng/ml). RESULTS: The mean values of most cardiometabolic variables tended to increase proportionally with serum ferritin quartiles. The proportion of women with IR and MetS significantly increased in accordance with serum ferritin quartiles. Compared to individuals in the lowest quartile, the ORs (95% CIs) in the highest quartile were 2.06 (1.23-3.45) for IR and 1.92 (1.44-2.55) for MetS after adjusting for age, cigarette smoking, alcohol intake, and regular exercise. CONCLUSION: Serum ferritin levels were positively and independently associated with IR and MetS in postmenopausal women. These findings suggest that serum ferritin level in postmenopausal women may help to identify the presence of IR and MetS.
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Authors | Mi-Ra Cho, Jin-Kyung Park, Won-Jun Choi, A-Ra Cho, Yong-Jae Lee |
Journal | Maturitas
(Maturitas)
Vol. 103
Pg. 3-7
(Sep 2017)
ISSN: 1873-4111 [Electronic] Ireland |
PMID | 28778329
(Publication Type: Journal Article)
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Copyright | Copyright © 2017 Elsevier B.V. All rights reserved. |
Chemical References |
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Topics |
- Biomarkers
(blood)
- Cross-Sectional Studies
- Female
- Ferritins
(blood)
- Humans
- Insulin Resistance
- Metabolic Syndrome
(blood)
- Middle Aged
- Nutrition Surveys
- Odds Ratio
- Postmenopause
(blood)
- Republic of Korea
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