Abstract | OBJECTIVE: DESIGN: We performed a prospective cohort study. SETTING: PATIENTS: INTERVENTIONS: MEASUREMENTS AND MAIN RESULTS: Detectable high-sensitivity troponin I was present in 94% of patients; 38% of patients had detectable levels below the 99th percentile of a healthy reference population (26 ng/L), whereas 56% of patients had levels above the 99th percentile cut point. After multivariable adjustment, age, cause of acute respiratory distress syndrome, temperature, heart rate, vasopressor use, Sequential Organ Failure Assessment score, creatinine, and PCO2 were associated with higher high-sensitivity troponin I concentration. After adjustment for age, sex, and randomized trial assignment, the hazard ratio for 60-day mortality comparing the fifth to the first quintiles of high-sensitivity troponin I was 1.61 (95% CI, 1.11-2.32; p trend = 0.003). Adjusting for Sequential Organ Failure Assessment score suggested that this association was not independent of disease severity (hazard ratio, 0.95; 95% CI, 0.64-1.39; p = 0.93). CONCLUSIONS:
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Authors | Thomas S Metkus, Eliseo Guallar, Lori Sokoll, David Morrow, Gordon Tomaselli, Roy Brower, Steven Schulman, Frederick K Korley |
Journal | Critical care medicine
(Crit Care Med)
Vol. 45
Issue 10
Pg. 1709-1717
(Oct 2017)
ISSN: 1530-0293 [Electronic] United States |
PMID | 28777195
(Publication Type: Journal Article)
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Chemical References |
- Troponin I
- Vasoconstrictor Agents
- Carbon Monoxide
- Creatinine
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Topics |
- Age Factors
- Carbon Monoxide
(blood)
- Cohort Studies
- Creatinine
(blood)
- Female
- Fever
(epidemiology)
- Heart Rate
- Humans
- Male
- Middle Aged
- Organ Dysfunction Scores
- Prevalence
- Prognosis
- Respiratory Distress Syndrome
(blood, mortality)
- Troponin I
(blood)
- Vasoconstrictor Agents
(therapeutic use)
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