SLC39A4 expression is associated with enhanced cell migration, cisplatin resistance, and poor survival in non-small cell lung cancer.

Abstract

The zinc transporter SLC39A4 influences epithelial cell morphology and migration in various cancers; however, its role in regulating cell invasion and chemotherapeutic resistance in human lung cancer is not yet clear. Here, integrated analysis of gene expression in non-small cell lung cancer revealed that SLC39A4 expression is significantly correlated with increased tumour size and regional lymph node spread, as well as shorter overall survival (OS) and disease-free survival (DFS). SLC39A4 silencing by lentivirus-mediated shRNA blocked human lung cancer cell epithelial-mesenchymal transition and metastasis in vitro and in vivo, respectively. Moreover, SLC39A4 knockdown enhanced cancer cell sensitivity to cisplatin-induced death by inhibiting stemness in lung cancer cells. Collectively, these data suggest that SLC39A4 may be a novel therapeutic target and predictive marker of tumour metastasis in non-small cell lung cancer.

• Authors: Dong-Ming Wu, Teng Liu, Shi-Hua Deng, Rong Han, Ying Xu
• Journal: Scientific reports (Sci Rep) Vol. 7 Issue 1 Pg. 7211 (08 03 2017) ISSN: 2045-2322 [Electronic] England
• PMID: 28775359 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Biomarkers, Tumor
• Cation Transport Proteins
• SLC39A4 protein, human
• Cisplatin

Topics

• Adult
• Aged
• Animals
• Antineoplastic Agents (pharmacology)
• Biomarkers, Tumor
• Carcinoma, Non-Small-Cell Lung (genetics, mortality, pathology)
• Cation Transport Proteins (genetics)
• Cell Line, Tumor
• Cell Movement
• Cisplatin (pharmacology)
• Disease Models, Animal
• Drug Resistance, Neoplasm (genetics)
• Female
• Gene Expression
• Gene Silencing
• Humans
• Kaplan-Meier Estimate
• Lung Neoplasms (genetics, mortality, pathology)
• Male
• Mice
• Middle Aged
• Neoplasm Metastasis
• Neoplasm Staging
• Prognosis
• Xenograft Model Antitumor Assays