Abstract | OBJECTIVE: METHODS: One hundred fifty-nine patients with PD, ET, and dystonia underwent VIM DBS due to refractory tremor at the Grenoble University Hospital. The primary outcome was a change in the tremor scores at 1 year after surgery and at the latest follow-up (21 years). Secondary outcomes included the relationship between tremor score reduction over time and the active contact position. Tremor scores (Unified Parkinson's Disease Rating Scale-III, items 20 and 21; Fahn, Tolosa, Marin Tremor Rating Scale) and the coordinates of the active contacts were recorded. RESULTS: Ninety-eight patients were included. Patients with PD and ET had sustained improvement in tremor with VIM stimulation (mean improvement, 70% and 66% at 1 year; 63% and 48% beyond 10 years, respectively; p < 0.05). There was no significant loss of stimulation benefit over time (p > 0.05). Patients with dystonia exhibited a moderate response at 1-year follow-up (41% tremor improvement, p = 0.027), which was not sustained after 5 years (30% improvement, p = 0.109). The more dorsal active contacts' coordinates in the right lead were related to a better outcome 1 year after surgery (p = 0.029). During the whole follow-up, forty-eight patients (49%) experienced minor side effects, whereas 2 (2.0%) had serious events ( brain hemorrhage and infection). CONCLUSIONS: VIM DBS is an effective long-term (beyond 10 years) treatment for tremor in PD and ET. Effects on dystonic tremor were modest and transient. CLASSIFICATION OF EVIDENCE: This provides Class IV evidence. It is an observational study.
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Authors | Rubens Gisbert Cury, Valerie Fraix, Anna Castrioto, Maricely Ambar Pérez Fernández, Paul Krack, Stephan Chabardes, Eric Seigneuret, Eduardo Joaquim Lopes Alho, Alim-Louis Benabid, Elena Moro |
Journal | Neurology
(Neurology)
Vol. 89
Issue 13
Pg. 1416-1423
(Sep 26 2017)
ISSN: 1526-632X [Electronic] United States |
PMID | 28768840
(Publication Type: Journal Article)
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Copyright | © 2017 American Academy of Neurology. |
Topics |
- Adult
- Aged
- Deep Brain Stimulation
(adverse effects)
- Dystonia
(physiopathology, therapy)
- Essential Tremor
(physiopathology, therapy)
- Female
- Follow-Up Studies
- Humans
- Male
- Middle Aged
- Parkinson Disease
(physiopathology, therapy)
- Retrospective Studies
- Treatment Outcome
- Ventral Thalamic Nuclei
(physiopathology)
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